The Immunomodulatory C3 Binding Glycoprotein Induces Il-12 and Changes Il-12/il-10 Ratio in Stimulated Human Pbmc
نویسندگان
چکیده
The induction of IL-12 and IL-10 production by the immunomodulatory C3 binding glycoprotein (C3bgp) was studied on human peripheral blood mononuclear cells (PBMC). Isolated PBMC from healthy human donors were cultured 24 hours with C3bgp isolated from Cuscuta europea. We studied also the influence of C3bgp on the cytokine production in LPS-, PHAand PWM-stimulated PBMC. The levels of these cytokines in the various culture supernatants were subsequently determined using
منابع مشابه
مقایسه سطح سیتوکاین های IL-5، IL-10، IL-12 و IL-18 مترشحه از سلول های PBMC در بیماران مبتلا به لیشمانیوز پوستی بهبود یابنده و غیر بهبود یابنده
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